Diagnosis of tamoxifen sensitivity

Details Diagnosis of tamoxifen sensitivity Diagnosis of tamoxifen sensitivity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2601020

Data indicate that adjuvant tamoxifen treatment adversely influences outcome in breas cancer with CCNDl-amplification and in fact severely promotes disease progress. The present invention thus relates to a method for diagnosing sensitivity to tamoxifen by monitoring the amplification of the gene for cyclin Dl, CCNDl.

Des données indiquent qu'un traitement adjuvant au tamoxifène influence négativement les résultats du cancer du sein par amplification du gène CCND1 et favorise en fait gravement la progression de la maladie. Cette invention concerne ainsi un procédé permettant de diagnostiquer la sensibilité au tamoxifène en surveillant l'amplification du gène de la cycline D1, CCND1.

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