Diagnosis of tauopathies determining tau/phospho-tau ratio

Details Diagnosis of tauopathies determining tau/phospho-tau ratio Diagnosis of tauopathies determining tau/phospho-tau ratio

G - Physics

01

N

G01N 33/68 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2397991

The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non- tauopathy based on the detection of the ratio of phospho-tau (181)/ total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.

La présente invention se rapporte à un procédé permettant de diagnostiquer une tauopathie chez un sujet et/ou d'effectuer un diagnostic différentiel entre une tauopathie et une non-tauopathie en fonction de la détection du rapport phospho-tau (181) / tau total chez ledit sujet. La présente invention se rapporte en outre à un phospho-peptide pouvant être utilisé aux fins de standardisation dans la mise en oeuvre d'un procédé tel que celui décrit ci-dessus.

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