C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
167/101, 260/212
C08L 3/08 (2006.01) A61K 49/00 (2006.01) A61K 51/12 (2006.01) C08B 31/00 (2006.01) C08L 3/06 (2006.01)
Patent
CA 1039274
ABSTRACT A diagnostic agent for intravascular administration, consisting of or containing a suspension of minute particles and a radioactive substance is provided, said particle having a size in the order of magnitude of 0.1 - 300 µ m. The suspension is more stable than those previously available, and is not as subject to sedimentation. The particles of the suspension decompose in sufficient time to avoid the serious consequences arising from a prolonged blockage of the blood vessels. In addition, the suspension is more resistant to heat and fluctuations in temperature. The agent consists of a suspension of minute particles which comprise a polysaccharide built up of glucose units or a physiolog- ically acceptable derivative of said polysaccharide in a physiolog- ically acceptable aqueous liquid. The particles comprise a water- insoluble, but hydrophilic, swellable, three-dimensional network of molecules of the polysaccharide, or of the derivatives thereof, cross-linked by means of bridges having bonds of a covalent nature. At least one radioactive substance is included in the agent and is bound to and/or enclosed in and/or exists in mixture with the minute particles. The network may be broken up by x-anylase in blood plasma into water-insoluble fragments within a time after injection that can be varied within wide limits. The suspension is prepared by suspending the minute particles in a physiologically acceptable aqueous liquid.
228779
Lindberg Bernt J.
Rothman Ulf S. E.
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