Diagnostic and prognostic compounds and method

Details Diagnostic and prognostic compounds and method Diagnostic and prognostic compounds and method

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/705 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2518058

The present invention relates to a method of diagnosing bacterial or fungal sepsis in a subject, which method comprises the step of measuring the level of TREM-1-Ligand or TREM-1-Ligand nucleic acid in a biological sample obtained from said subject. The method can involve contacting said biological sample with a compound capable of binding TREM-1-Ligand and detecting the level of TREM-1-Ligand present in the sample by observing the level of binding between said compound and TREM-1-Ligand. Compounds, compositions and kits for use in the diagnosis of bacterial or fungal sepsis are also provided.

La présente invention concerne une méthode de diagnostic de la sepsie bactérienne ou fongique chez un sujet, laquelle méthode consiste à mesurer le niveau de ligand du TREM-1 ou d'acide nucléique de ligand du TREM-1 dans un échantillon biologique prélevé sur ledit sujet. Cette méthode peut consister à mettre en contact cet échantillon biologique avec un composé capable de se lier au ligand du TREM-1 puis à détecter le niveau de ligand du TREM-1 présent dans cet échantillon en observant le niveau de liaison entre ce composé et le ligand du TREM-1. La présente invention concerne également des composés, des compositions et des trousses à utiliser dans le diagnostic de la sepsie bactérienne ou fongique.

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