Diagnostic and therapeutic application of ctl and nk...

G - Physics – 01 – N

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G01N 33/50 (2006.01)

Patent

CA 2649244

The invention proposes a novel therapeutic and diagnostic methodology based on the use of effector cells (for example CTL and NK cells) selected for being able to induce lysis in target cells. In particular, the invention teaches how to select strains of effector cells of the immune system according to their lytic properties. It also teaches how diagnostic procedures for checking the activity of therapeutic vaccines can be improved with respect to what shown. Finally, it shows how cell therapies used at present can be improved by using this approach.

L'invention concerne une nouvelle méthodologie thérapeutique et diagnostique basée sur l'utilisation de cellules effectrices (par exemple, des cellules CTL et NK) sélectionnées pour leur capacité à induire la lyse de cellules cibles. En particulier, l'invention permet de savoir comment sélectionner des souches cellules de effectrices du système immunitaire d'après leurs propriétés lytiques. Elle permet également de savoir comment les procédures de diagnostic pour vérifier l'activité de vaccins thérapeutiques peuvent être améliorées par rapport à ce qui est démontré. Finalement, elle montre comment les thérapies cellulaires utilisées à présent peuvent être améliorées grâce à une telle approche.

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