Diagnostic and therapeutic nucleotide or nucleoside...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 1/13 (2006.01) C07K 16/30 (2006.01) G01N 33/532 (2006.01) G01N 33/533 (2006.01) G01N 33/534 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2261898

Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. Such photoaffinity sites are contained on a conserved region of different antibody molecules. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical means. These mucleotide photoaffinity compounds may additionally be attached to molecules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.

On décrit des sites d'anticorps présentant une affinité pour des composés de photo-affinité, notamment des composés puriques ou azidopuriques. De tels sites de photo-affinité sont contenus dans une région conservée de différentes molécules d'anticorps. Ces sites permettent, grâce à des moyens photochimiques, une fixation régiospécifique de composés de photo-affinité nucléotidiques, sur des anticorps, par exemple des composés de photo-affinité analogues d'ATP ou de GTP. En outre, ces composés de photo-affinité nucléotidique peuvent se fixer sur des molécules présentant une activité diagnostique ou thérapeutique voulue, et les conjugués résultants peuvent être utilisés en tant qu'agents diagnostiques ou thérapeutiques.

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