Diagnostic and therapeutic system for crohn's disease and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 39/165 (2006.01) A61K 39/42 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2216807

The present invention relates to a diagnostic system for the detection of Crohn's disease and ulcerative colitis by means of nucleotide amplification reactions, in situ or in vitro which detection means are specific for the measles virus and are capable of distinguishing between the "wild" type and the attenuated measles virus strains. The invention further provides a use in the manufacture of a medicament for the treatment of Crohn's disease and/or ulcerative colitis which medicament comprises a suitable vector carrying antisense RNA to specific viral proteins which are consequently inhibited from being expressed in the host.

La présente invention se rapporte à un système diagnostique utilisé dans la détection de la maladie de Crohn et de la rectocolite hémorragique et réalisé au moyen de réactions d'amplification nucléotidique, in situ ou in vitro. Ces moyens de détection sont spécifiques du virus de la rougeole et peuvent faire la distinction entre les souches du virus de la rougeole de type "sauvage" et celles du virus de la rougeole atténué. L'invention se rapporte également à la fabrication d'un médicament utilisé dans le traitement de la maladie de Crohn et/ou de la rectocolite hémorragique, ce médicament comprenant un ARN antisens véhiculant un vecteur approprié dirigé contre des protéines virales spécifiques et inhibant, par conséquent, l'expression de ces protéines dans l'hôte.

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