A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 3/00 (2006.01) A61P 13/12 (2006.01) A61P 19/00 (2006.01) A61P 27/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2482634
The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g. tumors or diseases of the kidneys, bones and eyes, lipid and glucose metabolism and obesity. The present invention also relates to a pharmaceutical composition containing a compound which is capable of modifying (a) the expression of the gene encoding Kremen 1 and/or Kremen 2 or (b) the activity of the Kremen 1 and/or Kremen 2 receptor.
La présente invention concerne une composition utilisée dans le diagnostic et la thérapie de maladies associées à l'expression aberrante du gène codant le récepteur de Kremen 1 et/ou Kremen 2, par exemple des tumeurs ou maladies des reins, des os et des yeux, des troubles du métabolisme des lipides et du glucose et l'obésité. L'invention se rapporte également à une composition pharmaceutique contenant un composé capable de modifier : (a) l'expression du gène codant Kremen 1 et/ou Kremen 2 ; ou (b) l'activité du récepteur de Kremen 1 et/ou Kremen 2.
Mao Bingyu
Niehrs Christof
Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rech
Gowling Lafleur Henderson Llp
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