G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 16/24 (2006.01) C12N 15/19 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2405680
Methods for diagnosing risk of miscarriage and/or premature birth, foetal abnormalities, cancer (e.g. prostate cancer) and inflammatory disease (e.g. rheumatoid arthritis) are disclosed which involve determining abnormal levels of macrophage inhibitory cytokine-1 (MIC-1) in a body sample or, otherwise, determining the presence of a MIC-1 variant protein. Also disclosed are methods for reducing the risk of miscarriage and/or premature birth in pregnant subjects, and methods for treatment of inflammatory disease and/or cancer.
L'invention concerne des procédés d'établissement de risque diagnostic d'avortement spontané et/ou de naissance prématurée, d'anormalités foetales, de cancer (par exemple, de cancer de la prostate) et de maladie inflammatoire (par exemple, d'arthrite rhumatoïde) qui impliquent la détermination de niveaux anormaux de cytokine-1 inhibitrice macrophage (MIC-1) dans un échantillon corporel ou la détermination de la présence de protéine variante de MIC-1. L'invention concerne également des procédés permettant de réduire le risque d'avortement spontané et/ou de naissance prématurée chez des sujets gravides et des procédés de traitement de maladie inflammatoire et/ou de cancer.
Breit Samuel Norbert
Brown David Alexander
Bennett Jones Llp
St. Vincent's Hospital Sydney Limited
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