Diagnostic assay for stroke

G - Physics – 01 – N

Patent

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G01N 33/68 (2006.01)

Patent

CA 2393127

Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using a anti- H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish stroke from AMI requires an assay specific to AMI, e.g. using troponin-1 or CK-MB as a marker, also to be carried out.

Les protéines liant les acides gras du coeur et du cerveau (H-FABP, B-FABP) sont des marqueurs de l'accident vasculaire cérébral. L'invention concerne une épreuve diagnostique permettant de doser l'un ou l'autre de ces marqueurs, de préférence grâce à un ELISA faisant appel à un anticorps dirigé contre les H-FABP ou les B-FABP. Etant donné que la H-FABP est également un marqueur de l'infarctus aigu du myocarde, si l'on souhaite distinguer l'accident vasculaire cérébral de l'infarctus aigu du myocarde, il est nécessaire d'utiliser une épreuve spécifique de l'infarctus aigu du myocarde, par exemple en utilisant la troponine-1 ou le CK-MB comme marqueur.

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