Diagnostic assays for detection of cryptosporidium parvum

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/61 (2006.01) C07K 14/44 (2006.01) C07K 16/20 (2006.01) C12N 9/90 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2343879

This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The invention also provides methods, reagents, and kits that are useful for diagnosing infection by Cryptosporidium parvum. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the protein disulfide isomerase polypeptide of C. parvum.

L'invention concerne un nouveau polypeptide de protéine disulfure isomérase tiré de Cryptosporidium parvum ainsi que des acides nucléiques qui codent pour ce polypeptide. L'invention concerne également des méthodes, des réactifs et des trousses servant à diagnostiquer une infection à Cryptosporidium parvum. Ces méthodes sont fondées sur la découverte d'agents de liaison, y compris des anticorps polyclonaux recombinés, qui se lient au polypeptide de protéine disulfure isomérase de Cryptosporidium parvum.

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