Diagnostic for lung disorders using class prediction

Details Diagnostic for lung disorders using class prediction Diagnostic for lung disorders using class prediction

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2605158

The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, particularly in individuals who are exposed to air pollutants, such as cigarette or cigar smoke, smog, asbestos and the like air contaminants or pollutants.

L'invention concerne des méthodes de diagnostic et de pronostic du cancer du poumon, mettant en oeuvre une analyse d'expression pour au moins un groupe de gènes, et une combinaison d'analyse d'expression et de bronchoscopie. Les méthodes selon l'invention permettent d'obtenir une précision de détection du cancer du poumon bien supérieure à celle des autres méthodes de diagnostic et de pronostic du cancer du poumon actuellement disponibles. L'invention concerne encore des méthodes de diagnostic et de pronostic d'autres maladies pulmonaires, en particulier chez des individus exposés à des polluants atmosphériques, tels que la fumée de cigarette ou de cigare, le brouillard de pollution, l'amiante et autres contaminants ou polluants atmosphériques analogues.

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