A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 10/02 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2626499
The invention relates to kits and methods for aiding the diagnosis of Barrett's oesophagus or Barrett's associated dysplasia. Preferred is a method comprising assaying cells from the surface of a subject's oesophagus for a non- squamous cellular marker, wherein detection of such a marker indicates increased likelihood of the presence of Barrett's or Barrett's associated dysplasia, preferably wherein said sample of cells is not directed to a particular site within the oesophagus. The invention also encompasses a method comprising sampling the cellular surface of the oesophagus of said subject. The invention also relates to a kit comprising a swallowable device comprising abrasive material capable of collecting cells from the surface of the oesophagus, together with printed instructions for its use in detection of Barrett's oesophagus or Barrett's associated dysplasia. Preferably said device comprises a capsule sponge.
L~invention concerne des kits et des procédés facilitant le diagnostic de l~AEsophage de Barrett ou de la dysplasie associée de Barrett. L~invention concerne de préférence un procédé consistant à analyser des cellules de la surface de l~AEsophage d~un sujet pour détecter un marqueur cellulaire non squameux, caractérisé en ce que la détection d~un tel marqueur indique la probabilité accrue de la présence de l~AEsophage de Barrett ou de la dysplasie associée de Barrett, et de préférence caractérisé en ce que ledit échantillon de cellules ne concerne pas un site particulier dans l~AEsophage. L~invention comporte également un procédé consistant à échantillonner la surface cellulaire de l~AEsophage dudit sujet. L~invention concerne également un kit comprenant un dispositif que l~on peut avaler comprenant un matériau abrasif capable de collecter des cellules à la surface de l~AEsophage, avec des instructions imprimées pour son utilisation dans la détection de l~AEsophage de Barrett ou de la dysplasie associée de Barrett. De préférence ledit dispositif comprend une éponge de capsule.
Fitzgerald Rebecca C.
Hardwick Richard
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cambridge Enterprise Limited
Medical Research Council
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