G - Physics
01
N
G01N 33/68 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2281010
A method is provided for determining the susceptibility of a patient to post- operative atrial fibrillation (AF) which method comprises determining the levels of connexin40 in a sample of cardiac tissue taken from said patient wherein the presence in said sample of elevated levels of connexin40 is indicative of a susceptibility to post-operative atrial fibrillation (AF). Also provided is a method for preventing or treating post-operative atrial fibrillation in a patient which method comprises administering to said patient an effective amount of a substance capable of down regulating connexin40 expression or inhibiting connexin40 function and assays for identifying suitable substances.
Coppen Steven R.
Dupont Emmanuel
Haw Marcus P.
Ko Yu-Shien
Severs Nicholas J.
Gowling Lafleur Henderson Llp
Imperial College Of Science Technology And Medicine
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