Diagnostic method and probe

Details Diagnostic method and probe Diagnostic method and probe

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2195404

Introns and a new exon, Exon 9a, are formed as transcripts during uncontrolled expression of the CD44 gene in tumour cells. Novel probes comprise labelled oligonucleotides which hybridize to complementary strands synthesized on introns. A diagnostic method comprises hybridizing these probes with nucleic acids recovered from mammalian cells. Intron In-9 having a 474 bp sequence and Exon 9a having a 436 bp sequence.

Des introns et un nouvel exon, l'exon 9a, sont formés comme produits de transcription pendant l'expression non régulée du gène CD44 dans des cellules tumorales. De nouvelles sondes comprennent des oligonucléotides marqués qui s'hybrident avec des brins complémentaires produits par synthèse sur des introns. Un procédé diagnostique consiste à hybrider ces sondes avec des acides nucléiques provenant de cellules de mammifères. On décrit l'intron In-9 doté d'une séquence 474 bp et l'exon 9a doté d'une séquence 436 bp.

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