Diagnostic method based on quantification of...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2330840

Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.

L'invention concerne des compositions et des méthodes basées sur la quantification de séquences d'ADN extramitochondrial (ADNexmt) utiles pour détecter la présence d'une maladie ou le risque d'avoir une maladie associée à une fonction mitochondriale modifiée, et pour identifier des agents adaptés au traitement de ces maladies. Les séquences d'ADNexmt ont une forte homologie avec des séquences d'ADN mitochondrial authentiques (ADNmt).

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