Diagnostic method for brain damage-related disorders

G - Physics – 01 – N

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G01N 33/68 (2006.01)

Patent

CA 2532130

A brain damage-related disorder is diagnosed in a subject by detecting at least one polypeptide, or a variant or mutant there« selected from A-FABP, E- FABP, PGP 9.5, GFAP, Prostaglandin D synthase, Neuromodulin, Neurofflament L, Calcyphosine, RNA binding regulatory subunit, Ubiquitin fusion degradation protein 1 homolog, Nucleoside diphosphate Idnase A, Glutathione S tranférase P, Cathepsin D, DJ-1 protein, Peroxiredoxin 5 and Peptidyl-prolyl cis-trans isomerase A (Cyclophilin A) in a sample of body fluid taken from the subject.

Un trouble associé à une liaison cérébrale est diagnostiqué chez un patient par détection d'au moins un polypeptide, d'une variante ou d'un mutant de celui-ci, sélectionné dans le groupe comprenant A-FABP, E-FABP, PGP 9.5, GFAP, la prostaglandine D synthase, la neuromoduline, le neurofilament L, la calcyphosine, une sous-unité de régulation de liaison de l'ARN, un homologue de la protéine 1 de dégradation de fusion de l'ubiquitine, la nucléoside diphosphate kinase A, la glutathione S tranférase P, la cathepsine D, la protéine DJ-1, le peroxiredoxine 5 et la peptidyle-prolyle cis-trans isomerase A (cyclophiline A), dans un échantillon de fluide corporel du patient.

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