C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2380646
Determining the presence of cancerous or pre-cancerous cervical lesions from ASCUS-diagnosed Pap smear cells by observing the distribution of MN/CA9 antigen expressed on atypical or normal cells and diagnosing (a) significant lesions when MN/CA9 antigen is observed on atypical cells, (b) low grade lesions when MN/CA9 antigen is absent from atypical cells but is present on normal endocervical cells, and (c) a benign condition when MN/CA9 antigen is absent from both atypical cells and normal endocervical cells.
L'invention concerne la détermination de la présence de lésions cervicales cancéreuses ou précancéreuses à partir de cellules de tests de Papanicolaou diagnostiquées ASCUS. Cette détermination consiste à observer la répartition de l'antigène MN/CA9 exprimé dans des cellules atypiques ou normales et à diagnostiquer (a) des lésions importantes lorsque l'on observe l'antigène MN/CA9 dans des cellules atypiques, (b) des lésions de moindre importance lorsque l'antigène MN/CA9 est absent des cellules atypiques mais présent dans des cellules endocervicales normales, et (c) une condition bénigne lorsque l'antigène MN/CA9 est absent à la fois des cellules atypiques et des cellules endocervicales normales.
Liao Shu-Yuan
Stanbridge Eric J.
Smart & Biggar
The Regents Of The University Of California
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