Diagnostic methods and genetic markers for alzheimer disease

A - Human Necessities – 61 – K

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A61K 31/12 (2006.01) A61K 31/136 (2006.01) A61K 31/222 (2006.01) C07C 49/235 (2006.01) C07C 49/248 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2663954

Disclosed are methods for identifying individuals suffering from a CNS disorder (including Alzheimer's Disease, behavioral disorders, and the like) that could be treated with a CNS drug with greater therapeutic efficacy and lower side effects and the compounds useful for such treatment. Also disclosed are methods for predicting the efficacy of a drug candidate for the treatment of a CNS disorder. The technology is also applicable to drug discovery for use in animal models of neurodegenerative diseases.

L'invention concerne des procédés pour identifier des individus souffrant d'un trouble du système nerveux central (SNC) (y compris la maladie d'Alzheimer, des troubles du comportement, et analogues) qui pourraient être traités avec un médicament agissant sur le système nerveux central présentant une plus grande efficacité thérapeutique et des effets secondaires moindres, ainsi que les composés utiles pour un tel traitement. L'invention décrit également des procédés permettant de prévoir l'efficacité d'un médicament candidat pour le traitement d'un trouble du SNC. La technologie est également applicable à la découverte de médicaments pouvant être utilisés sur des modèles de maladies neurodegénératives de l'animal.

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