C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/705 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2448484
A method for determining propensity toward developing a cardiovascular disease in a patient at risk thereof by determining the presence in an ABCA1 gene of said patient of a polymorphism in the DNA sequence of the gene wherein said polymorphism is present in a non-coding region of said gene is disclosed. Also described is a method of identifying a modulator of ABCA1 polynucleotide expression comprising by determining the ability of a test compound to modulate the activity of a polynucleotide comprising a polymorphism disclosed herein, or to mimic the effects of such polymorphism where such effects are beneficial. Treatment of cardiovascular disease, especially coronary artery disease, using agents identified by the disclosed methods is also described.
L'invention concerne un procédé destiné à déterminer la propension à développer une maladie cardio-vasculaire chez un patient à risque par détermination de la présence dans un gène ABCA1 dudit patient d'un polymorphisme dans la séquence d'ADN de ce gène, ce polymorphisme étant présent dans une zone non codante du gène. L'invention concerne également un procédé destiné à identifier un modulateur de l'expression polynucléotidique ABCA1 consistant à déterminer la capacité d'un composant test à moduler l'activité d'un polynucléotide renfermant un polymorphisme, ou à imiter les effets d'un tel polymorphisme lorsque ces effets sont bénéfiques. L'invention concerne enfin le traitement d'une maladie cardio-vasculaire, notamment la coronaropathie, au moyen d'agents identifiés par les procédés de l'invention.
Clee Susanne M.
Hayden Michael R.
Zwarts Karin Yvon
Smart & Biggar
University Of British Columbia
Xenon Genetics Inc.
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