Diagnostic methods for detecting lymphomas in humans

Details Diagnostic methods for detecting lymphomas in humans Diagnostic methods for detecting lymphomas in humans

C - Chemistry, Metallurgy

12

Q

530/13, 167/37,

C12Q 1/68 (2006.01) C07K 14/82 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 1340827

The sequence of the protein coding regions of the bc1-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to this translocation break-point.

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