Diagnostic probe for diabetes type i predisposition

Details Diagnostic probe for diabetes type i predisposition Diagnostic probe for diabetes type i predisposition

C - Chemistry, Metallurgy

07

H

195/1.12, 150/8.

C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 1299506

DIAGNOSTIC PROBE FOR DIABETES TYPE I PREDISPOSITION Abstract An oligonucleotide probe for diagnosing predisposition or susceptibility to type I diabetes, capable of specifically hybridizing with the gene sequence Image or Image wherein A is adenine, C is cytosine, G is guanine, T is thymine, and R is thymine or uracil. The probe may include at least 15 sequential nucleotides selected from the sequence Image or Image . The probe may be labeled with a detectable marker, such as an enzyme or biotin, and may be supplied in a diagnostic kit in combination with: a substratum capable of adsorbing DNA or cells, a restriction enzyme, and/or a detergent.

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