Diagnostic procedures using 129xe spectroscopy...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) A61B 5/0275 (2006.01) A61B 5/055 (2006.01) G01R 33/28 (2006.01)

Patent

CA 2414610

An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized 129Xe spectroscopy is disclosed. Generally stated, the method includes determining the magnitude of spectral peaks which represent particular chemical shifts and comparing the observed magnitudes to those of healthy individuals. Preferably, the method includes subtracting substantial backgrounds and accounting for secondary conditions such as the polarization of hyperpolarized gas administered. Additionally, a quantitative analysis of hyperpolarized 129Xe spectra advantageously allows a physician to establish the extent of disease progression. Advantageously, this method can be used regardless of the method of hyperpolarized 129Xe administration.

Cette invention concerne une méthode in vivo non effractive permettant de détecter et/ou de diagnostiquer un état pathologique au moyen d'une spectroscopie au ?129¿Xe hyperpolarisé. De façon générale, cette méthode consiste à déterminer l'amplitude de crêtes spectrales représentant des déplacements chimiques et à comparer les amplitudes relevées à celles observables chez des individus sains. Il convient de préférence de faire abstraction d'arrières plans substantiels et de prendre en compte des états secondaires tels que la polarisation du gaz hyperpolarisé administré. De plus, une analyse quantitative du spectre de ?129¿Xe hyperpolarisé permet au médecin de déterminer l'ampleur de la progression de la maladie. Cette méthode offre l'avantage de pouvoir être utilisée indépendamment du procédé d'administration du ?129¿Xe hyperpolarisé.

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