G - Physics – 01 – N
Patent
G - Physics
01
N
260/425, 167/47,
G01N 33/534 (2006.01) A61K 51/04 (2006.01)
Patent
CA 1189860
Abstract of the Disclosure A radiopharmaceutical chemical compound comprising a radioactive isotope, other than an isotope of iodine, in chemical combination with at least one amine group. The compound has a lipophilicity sufficiently high at a pH of 7.6 to permit passage of the compound from the blood of a mammal into a target organ or tissue and sufficiently low at a pH of 6.6 to prevent rapid return of the compound from the target organ or tissue to the blood. The compound has a percent protein binding of less than ninety percent. A method for selectively depositing a radiopharmaceutical compound in at least one target tissue or organ of a mammal, which tissue or organ has a significantly different intracellular pH than the blood of the mammal, by introducing the compound of the invention into the bloodstream of the mammal.
359340
Blau Monte
Kung Hank F.
Gowling Lafleur Henderson Llp
State University Of New York
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