Diagnostic reagent for rheumatoid factor, process for its...

Details Diagnostic reagent for rheumatoid factor, process for its... Diagnostic reagent for rheumatoid factor, process for its...

G - Physics

01

N

167/44

G01N 33/546 (2006.01) G01N 33/543 (2006.01) G01N 33/564 (2006.01)

Patent

CA 1226217

ABSTRACT DIAGNOSTIC REAGENT FOR RHEUMATOID FACTOR, PROCESS FOR ITS PREPARATION AND METHOD AND KIT FOR ITS USE A suspension of particles such as carboxylated polystyrene latex particles are coated (as by carbide- imide coupling) with an antigen (such as chemically modified Bovine Serum Albumin). The antigen-coated particles are incubated with a gamma-globulin to the antigen (such as can be produced by immunizing rabbits) under non-agglutinating conditions. The particles having antigen/gamma-globulin immune complexes are recovered and resuspended to form a diagnostic reagent which agglutinates when mixed with human serum containing Rheumatoid Factor.

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