Diagnostic test for pseudomonas aeruginosa infections

Details Diagnostic test for pseudomonas aeruginosa infections Diagnostic test for pseudomonas aeruginosa infections

C - Chemistry, Metallurgy

12

N

167/37, 195/1.10

C12N 5/18 (2006.01) C07K 14/21 (2006.01) C07K 16/12 (2006.01) G01N 33/569 (2006.01)

Patent

CA 1340816

Methods and reagents are provided for a novel immunodiagnostic test for the presence of P. aeruginosa in a biological sample. Monoclonal antibodies are employed which bind to an outer membrane protein antigen, which may be exposed by a solubilizing reagent. The antibody binds substantially all strains of P. aeruginosa. No cross-reactivity with other species of Pseudomonas or with other clinically significant gran-negative or gram-positive species is observed. Conjugating the monoclonal antibody of the invention with a fluorescent label provides for a rapid and sensitive direct immunofluorescent test for P. aeruginosa.

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