Diagnostics and treatments for cancers expressing tyrosine...

Details Diagnostics and treatments for cancers expressing tyrosine... Diagnostics and treatments for cancers expressing tyrosine...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2190161

The invention relates to methods and kits for diagnosing cancers arising from cells which express tyrosine phosphorylated CRKL protein, such as cells having the Philadelphia (Ph) chromosome, which includes chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL), through the detection of increased levels of phosphorylated CRKL protein or through the detection of increased CRKL, or CRKL binding protein, or a CRKL binding protein, gene copy of mRNA expression. The invention also relates to methods of treating such cancers.

L'invention concerne des procédés et des matériels de diagnostic de cancers ayant pour origine des cellules exprimant la protéine CRKL phosphorylée sur tyrosine, telles que des cellules présentant le chromosome Philadelphie (Ph), y compris la leucémie myéloïde chronique (LMC) et la leucémie lymphoblastique aigüe (LLA), par la détection de niveau accru de protéine CRKL phosphorylée ou par la détection de CRKL accrue, ou bien une protéine de liaison de CRKL, ou une protéine, une copie de gène ou une expression d'ARNm liant la CRKL. L'invention concerne également des procédés de traitement de ces cancers.

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