Diagnostics and vaccines for mycobacteria in public health,...

Details Diagnostics and vaccines for mycobacteria in public health,... Diagnostics and vaccines for mycobacteria in public health,...

C - Chemistry, Metallurgy

12

N

530/13, 167/135,

C12N 15/31 (2006.01) A61K 39/04 (2006.01) C07H 21/00 (2006.01) C07K 14/35 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1340172

The invention relates to a family of DNA insertion sequences (ISMY) of mycobacterial origin and other DNA probes which may be used as probes in assay methods for the identification of mycobacteria and the differentiation between closely related mycobacterial strains and species. In one method the probes are used to distinguish pathogenic M. paratuberculosis from M. avium, which finds an application in the diagnosis of Crohn's disease in humans and Johne's disease in animals. The use of ISMY, and of proteins and peptides encoded by ISMY, in vaccines, pharmaceutical preparations and diagnostic test kits is also disclosed.

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