Diagnostics for aging-related dermatologic disorders

Details Diagnostics for aging-related dermatologic disorders Diagnostics for aging-related dermatologic disorders

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2705142

The present invention provides methods for the early prediction of aging- related dermatologic conditions of including skin changes associated with intrinsic aging or skin damages caused by extrinsic aging such as photoaging. The present invention also provides kits for the early determination of the propensity to develop such disorder and conditions. The method consists of detecting the presence of one or more alleles of an IL-I haplotype or pattern, specifically the IL-IRN (+2018) and the EL-IB (-511) loci. The presence of allele 2 at the IL-IRN (+2018) and the EL-IB (-511) loci indicates decreased risk for a early onset of aging related dermatologic conditions.

La présente invention porte sur des procédés pour la prédiction précoce d'états dermatologiques liés au vieillissement comprenant des changements de peau associés au vieillissement intrinsèque ou à des dommages à la peau provoqués par le vieillissement intrinsèque tel que le photovieillissement. La présente invention porte également sur des trousses pour la détermination précoce de la propension à développer de tels troubles et états. Le procédé consiste à détecter la présence d'un ou de plusieurs allèles d'un haplotype ou motif IL-I, notamment les loci IL- IRN (+2018) et EL-IB (-511). La présence d'allèle 2 au niveau des loci IL-IRN (+2018) et EL-IB (-511) indique un risque diminué pour un début précoce d'états dermatologiques liés au vieillissement.

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