Diagnostics for and mediators of inflammatory disorders

Details Diagnostics for and mediators of inflammatory disorders Diagnostics for and mediators of inflammatory disorders

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2237191

A method and kit for the diagnosis and quantification of the state of oxidation, and more specifically, the level of lipid peroxidation, of a host is provided that includes contacting a host biological sample with an antibody to an antigen formed by the reaction of a lipid hydroperoxide with a primary amine. This method assesses the risk of, or existence of, oxidative damage in the host. The invention also includes monoclonal and polyclonal antibodies, as well as antibody fragments, optionally in purified or isolated form, which are useful in this method and kit.

Méthode et nécessaire pour le diagnostic et la quantification de l'état d'oxydation, et plus spécifiquement, du taux de peroxydation lipidique, d'un hôte. Ladite méthode consiste à mettre un échantillon biologique d'un hôte, comprenant un anticorps dirigé contre un antigène formé par la mise en réaction d'un hydroperoxyde lipidique, avec une amine primaire. Cette méthode permet d'évaluer le risque ou l'existence de dommage oxydatif dans l'hôte. L'invention concerne également des anticorps monoclonaux et polyclonaux ainsi que des fragments d'anticorps, éventuellement sous forme purifiée ou isolée, qui sont utiles dans le procédé et le nécessaire de l'invention.

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