Diagnostics for membranous nephropathy

Details Diagnostics for membranous nephropathy Diagnostics for membranous nephropathy

G - Physics

01

N

G01N 33/564 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2731065

The invention relates to immunoassays, reagents, therapeutics and methods of diagnosing and prognosis evaluation of idiopathic membranous nephropathy (MN). Immunoassays comprise enzyme-linked immunoabsorbent assays and nephelometric immunoassays for serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R). Therapeutic methods include removal of the auto-antibodies by adsorbance or administration of soluble PLA2R or fragments to sequester the auto-antibodies.

L'invention concerne des immuno-essais, des réactifs, des agents thérapeutiques et des procédés de diagnostic et de pronostic d'évaluation d'une néphropathie membraneuse idiopathique (MN). Des immuno-essais comportent des analyses dimmuno-adsorbants liés à une enzyme, et des immuno-essais néphélométriques pour des auto-anticorps de sérum réactifs à un récepteur de phospholipase A2 (PLA2R). Des procédés thérapeutiques comprennent l'élimination des auto-anticorps par procédé adsorbant ou par ladministration de PLA2R soluble ou de fragments pour séquestrer les auto-anticorps.

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