Dialdehyde treatment of diphtheria toxin and derivative...

Details Dialdehyde treatment of diphtheria toxin and derivative... Dialdehyde treatment of diphtheria toxin and derivative...

A - Human Necessities

61

K

167/135

A61K 39/02 (2006.01) A61K 39/05 (2006.01) F27B 3/10 (2006.01)

Patent

CA 1059026

DERIVATIVE OF DIPTHERIA TOXIN. PROCESS FOR PREPARING THEM AND AGENTS CONTAINING THEM Abstract of the disclosure: Process for preparing a derivative of the fragment B of diphtheria toxin, which comprises treating an aqueous solution of the diphtheria toxin with an aliphatic mono- or di-aldehyde having a chain length of 1 to 6 carbon atoms at an aldehyde con- centration of 0.0015 M to 0.035 M, at 1° to 20° C, for 5 minutes to 50 hours, reacting the toxin, before or after the treatment with aldehyde, in the presence of a compound splitting off di-sulfide bridges, with a proteolytic enzyme, recovering the derivative of fragment B from the solution obtained in the pre- sence of a denaturing agent by protein-chemical isolation pro- cesses and separating it from the denaturing agent. Vaccines may be prepared using these derivatives of diphtheria toxin.

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