C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/40 (2006.01) C07F 9/547 (2006.01) C07F 9/572 (2006.01) C07F 9/58 (2006.01) C07F 9/6506 (2006.01) C07F 9/6571 (2006.01)
Patent
CA 2102303
2102303 9222559 PCTABS00018 Provided are novel dialkyl (dialkoxyphosphinyl)methyl phosphates of formula (IV) which are useful as anti-inflammatory and anti-arthritic agents. The compounds are synthesized from the reaction of tetraethyl oxiranylidenebisphosphonate and unsubstituted or alkyl-amines. Representative compounds include 2-(benzylamino)-1-(diethoxyphosphinyl)ethyl phosphonic acid diethyl ester, 1-(diethoxyphosphinyl)-2-[2'-(1',2',3',4'-tetrahydro)napthylamino]ethyl phosphonic acid diethyl ester, 2-(3-fluorobenzylamino)-1-(diethoxyphosphinyl)ethyl phosphonic acid diethyl ester, and 5,5-dimethyl-2-[2-(3-fluorobenzyl)amino-1-[(5,5-dimethyl-1,3,2-dioxaphosphorin_ an-2-yl)oxy]ethyl]-1,3,2-dioxaphosphorinane P,2-dioxide.
Macrae & Co.
Pharmacia & Upjohn Company Llc
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