Dialkylamino alkyl esters of pivagabine as medicaments for...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/088 (2006.01) A61K 31/221 (2006.01) A61K 31/5375 (2006.01) C07C 231/12 (2006.01) C07C 233/47 (2006.01) C07D 207/08 (2006.01) C07D 209/02 (2006.01) C07D 211/22 (2006.01) C07D 215/20 (2006.01) C07D 217/04 (2006.01) C07D 221/04 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2670613

The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.

Les modes de réalisation de cette invention concernent le composé de formule 1 ou de formule 2 ci-dessous, leurs formulations pharmaceutiques, ainsi que des traitements destinés à un grand nombre de troubles du système nerveux central et utilisant lesdites formulations pharmaceutiques. Certains modes de réalisation comprennent l'utilisation d'un certain nombre des composés donnés qui présentent, curieusement et avantageusement, des profils pharmacocinétiques et thérapeutiques meilleurs que ceux de la pivagabine.

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