A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 1/16 (2006.01) A61M 1/18 (2006.01) B01D 61/28 (2006.01) B01D 63/02 (2006.01) B01D 67/00 (2006.01) B01D 69/08 (2006.01) B01D 71/58 (2006.01) B01D 71/68 (2006.01) D01D 5/24 (2006.01)
Patent
CA 2329103
The present invention relates to a dialyzer for blood treatment having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the water permeating performance of the semipermeable membrane after drying being 1/2 or higher relative to that before drying and the dialyzer satisfying any of the following requirements: (A) the vitamin B12 clearance is not smaller than 135 ml/min per 1.6 m2; and (B) the amount of the hydrophilic polymer that is eluted from the semipermeable membrane is not higher than 10 ppm. The invention also relates to a process for producing a dialyzer having incorporated therein a semipermeable membrane which comprises a hydrophobic polymer and a hydrophilic polymer, the process comprising: drying the semipermeable membrane; and saturating the dried semipermeable membrane with water ratio of not smaller than 100% based on the dry weight of the semipermeable membrane, providing an inert gas atmosphere to the inside of the dialyzer, and then irradiating the semipermeable membrane with gamma-ray in the inert gas atmosphere. The invention further relates to a process for producing a hollow fiber membrane for use in blood treatment through dry/wet spinning from a stock solution comprising 15 to 18% by weight of a hydrophobic polymer and 4 to 8% by weight of a hydrophilic polymer, the dry zone being filled with dry mist. The dialyzer includes a dry-type semipermeable membrane having less change in performance before and after drying and high water permeability and dialyzing performance, is light-weight, easy to handle, and exhibits a reduced elution of a hydrophilic polymer.
Kozawa Hidetoshi
Nakashima Hidekazu
Wada Shigehisa
Smart & Biggar
Toray Industries Inc.
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