C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/343 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/443 (2006.01) A61P 31/14 (2006.01) C07D 307/79 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2716348
Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.
L'invention concerne des méthodes d'inhibition d'enzymes du cytochrome P450 pouvant être utilisées pour améliorer le traitement de maladies en empêchant la dégradation de médicaments ou d'autres molécules par le cytochrome P450. L'invention concerne également des compositions pharmaceutiques qui peuvent faire office de renforçateurs pour améliorer la pharmacocinétique, augmenter la biodisponibilité et augmenter l'effet thérapeutique de médicaments qui subissent une dégradation in vivo par des enzymes du cytochrome P450.
Duan Dehui
Eissenstat Michael
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sequoia Pharmaceuticals Inc.
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