Diamido thiazole derivatives as protein kinase inhibitors

Details Diamido thiazole derivatives as protein kinase inhibitors Diamido thiazole derivatives as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2703980

The present invention relates to novel Diamido Thiazole Derivatives of structure I, compositions comprising the Diamido Thiazole Derivatives, and methods for using the Diamido Thiazole Derivatives for treating or preventing a proliferative disorder, an anti -proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase. Formula (I) wherein: M is -C(O)-, -C(S)-. -S(O)-. -S(O)2-. -NHS(O)2-. -OC(O)- or -NHC(O)-; Q is:formula (II).

L'invention concerne de nouveaux dérivés de diamidothiazole de structure I, des compositions comprenant les dérivés de diamidothiazole et des procédés pour utiliser les dérivés de diamidothiazole pour le traitement ou la prévention d'un trouble prolifératif, d'un trouble antiprolifératif, d'une inflammation, de l'arthrite, d'un trouble du système nerveux central, d'une maladie cardio-vasculaire, de l'alopécie, une maladie neuronale, d'une atteinte ischémique, d'une infection virale, d'une infection fongique ou d'un trouble associé à l'activité d'une protéine kinase. Formule (I) dans laquelle : M est -C(O)-, -C(S)- ; -S(O)- ; -S(O)2- ; -NHS(O)2- ; -OC(O)- ou -NHC(O)- ; Q est :

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