Diamine and iminodiacetic acid hydroxamic acid derivatives

Details Diamine and iminodiacetic acid hydroxamic acid derivatives Diamine and iminodiacetic acid hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) A61K 31/395 (2006.01) C07D 209/14 (2006.01) C07D 215/38 (2006.01) C07D 231/56 (2006.01) C07D 277/82 (2006.01) C07D 295/185 (2006.01) C07D 317/66 (2006.01) C07D 319/18 (2006.01)

Patent

CA 2547356

The present invention relates to a novel class of hydroxamic acid derivatives having a diamine or iminodiacetic acid backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively including terminal differentiation, arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells, Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compound of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives, and safe, dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

L'invention concerne une nouvelle classe de dérivés d'acide hydroxamique contenant un squelette d'acide diamine ou iminodiacétique. Ces composés d'acide hydroxamique peuvent être utilisés dans le traitement du cancer. Ces composés peuvent également inhiber l'histone déacétylase et ils peuvent être utilisés pour induire de manière sélective une différenciation terminale, pour arrêter la croissance cellulaire et/ou l'apoptose de cellules néoplasiques, ce qui permet d'inhiber la prolifération de ces cellules. Les composés selon l'invention sont donc utiles pour traiter un patient présentant une tumeur se caractérisant par la prolifération de cellules néoplasiques. Lesdits composés sont également utiles dans la prévention et le traitement des maladies induites par TRX, telles que les maladies auto-immunes, les maladies allergiques et les maladies inflammatoires, et dans la prévention et/ou le traitement des maladies du système nerveux central (SNC), telles que les maladies neurodégénératives. L'invention concerne encore des compositions pharmaceutiques contenant ces dérivés d'acide hydroxamique, ainsi que des schémas posologiques de dosage sûrs et faciles à suivre pour ces compositions. Lesdits schémas prévoient une quantité thérapeutiquement efficace de dérivés d'acide hydroxamique in vivo.

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