C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 243/08 (2006.01) A61K 31/165 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07C 211/27 (2006.01) C07C 211/49 (2006.01) C07C 217/56 (2006.01) C07C 237/04 (2006.01) C07C 271/28 (2006.01) C07C 275/34 (2006.01) C07C 275/40 (2006.01) C07C 311/29 (2006.01) C07C 327/28 (2006.01) C07C 327/30 (2006.01) C07D 233/02 (2006.01) C07D 245/02 (2006.01) C07D 295/13 (2006.01)
Patent
CA 2087604
The present invention provides a diamine compound of formula (I) or an acid addition salt thereof: Image wherein R1, R2, R3, R4, R5 and R6 are the same or different from each other and represent individually a hydrogen atom, halogen atom, hydroxyl group, lower alkyl group, lower alkoxy group, lower acyloxy group, lower alkoxycarbonyloxy group, lower alkylsulfonyloxy group or am amino group, among which the lower alkyl group and lower alkoxy group may be substituted by a halogen atom or a phenyl group; R7 and R8 are the same or different from each other and represent individually a lower alkyl group or the two bind to each other to represent an alkylene group having 1 to 4 carbon atoms; A and A' are the same or different from each other and represent individually a single bond, -O-, -NH-, -NHCO->, -CONH->, -NHCOO->, NHCONH-, -SO2NH-> or -COS-> (here, the symbol '->' denotes a bond to Y or Y'), Y and Y' are the same or different from each other and represent a lower alkylene- group or lower alkenylene group; and cerebral protective drugs containing such compound. The diamine compounds (I) or its acid addition salts have an excellent cerebral protective action, are very safe, and exhibit a strong action when even orally administered, and therefore, medicines containing such compounds are effective for treating disorders caused by cerebral hemorrhage, cerebral infarction, subarachnoid hemorrhage, transient ischemic attack, cerebrovascular disorders and the like, or preventing progress of such disorders.
Kawamura Kiyoshi
Ohta Tomio
Sato Seiichi
Shimizu Sadahiro
Takahashi Yoshio
Gowling Lafleur Henderson Llp
Kowa Co. Ltd.
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