Diaminediols for the treatment of alzheimer's disease

Details Diaminediols for the treatment of alzheimer's disease Diaminediols for the treatment of alzheimer's disease

C - Chemistry, Metallurgy

07

D

C07D 277/56 (2006.01) A61K 31/164 (2006.01) A61K 31/165 (2006.01) A61K 31/27 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61P 25/28 (2006.01) C07C 235/84 (2006.01) C07C 255/44 (2006.01) C07C 271/20 (2006.01) C07C 323/42 (2006.01) C07D 213/82 (2006.01) C07D 233/70 (2006.01) C07D 263/34 (2006.01) C07D 263/48 (2006.01)

Patent

CA 2453444

The present invention relates to compounds of formula (I) useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

La présente invention concerne des composés de formule (I) pouvant être utilisés dans le traitement de la maladie d'Alzheimer et d'autres maladies semblables. Lesdits composés comprennent des inhibiteurs de l'enzyme bêta-sécrétase qui peuvent être utilisés dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt d'un peptide bêta-amyloïde chez un mammifère. Les composés selon l'invention peuvent être utilisés dans des compositions pharmaceutiques et dans des méthodes de traitement destinées à réduire la formation de peptide bêta-amyloïde.

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