Diamino-benzylpyrimidines

Details Diamino-benzylpyrimidines Diamino-benzylpyrimidines

C - Chemistry, Metallurgy

07

D

260/262.5

C07D 239/48 (2006.01)

Patent

CA 1091673

ABSTRACT OF THE DISCLOSURE A method is provided for preparing a 2,4-diamino- 5-benzylpyrimidine of the formula (XI): Image (XI) for example, trimethoprim, which requires no unusual apparatus or reaction conditions, and proceeds with high yields; the method comprises reacting a benzyl cyanoacetal of formula (I): Image (I) wherein R1, R2 and R3 are the same or different and each is a halogen or hydrogen atom, an alkoxy group, an alkyl group or a dialkylamino group; R4 is an alkoxycarbonyl group, or an aldehyde group; and R5 is an alkyl group; the alkyl or alkoxy groups each having from 1 to 4 carbon atoms, with guanidine in a solvent compatible with and capable of dis- solving both reactants; the benzylcyanoacetals can be pre- pared in good yield from readily available materials.

348327

Affiliated with

Also associated with

Rating

Diamino-benzylpyrimidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diamino-benzylpyrimidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diamino-benzylpyrimidines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-726959