Diamino-pyridine, pyrimidine, and pyridazine modulators of...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) A61K 31/44 (2006.01) A61K 31/496 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 213/74 (2006.01) C07D 237/20 (2006.01) C07D 239/48 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2727684

Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

L'invention porte sur des composés diamino-pyridines, pyrimidines et pyridazines qui peuvent être utilisés comme modulateurs du récepteur H4, et sur des compositions pharmaceutiques et des procédés pour le traitement d'états morbides, de troubles et d'affections à médiation par l'activité du récepteur H4, tels qu'une allergie, l'asthme, des maladies auto-immunes et le prurit.

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