Diamino-pyrimidines and their use as angiogenesis inhibitors

Details Diamino-pyrimidines and their use as angiogenesis inhibitors Diamino-pyrimidines and their use as angiogenesis inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2477505

Benzimidazole derivatives of formula (I) , which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. (I)

L'invention concerne des dérivés de benzimidazole de formule (I), utiles en tant qu'inhibiteurs de TIE-2 et/ou de VEGFR-2. Elle concerne aussi des procédés de fabrication de ces dérivés de benzimidazole ainsi que des méthodes d'utilisation de ces composés dans le traitement de maladies hyperprolifératives.

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