Diaminoalkane aspartic protease inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/22 (2006.01) A61K 31/166 (2006.01) A61K 31/445 (2006.01) A61K 31/5375 (2006.01) A61P 9/12 (2006.01) C07C 235/42 (2006.01) C07D 211/56 (2006.01) C07D 265/30 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2582202

Diaminoalkanes of Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method for the use of the compounds of Formula I in ameliorating or treating aspartic protease related disorders in a subject in need thereof comprising administering to said subject an effective amount of a compound of Formula I.

La présente invention a trait à des diaminoalcanes de formule (I) présentant une activité orale et de liaison aux protéases aspartiques pour l'inhibition de leur activité. Ils sont utiles dans le traitement et l'amélioration de maladies associées à de niveaux élevés d'activité des protéases aspartiques. L'invention a également trait à un procédé pour l'utilisation des composés de formule (I) dans l'amélioration ou le traitement de troubles liés aux protéases aspartiques chez un sujet qui en a besoin comprenant l'administration au dit sujet d'une quantité efficace d'un composé de formule (I).

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