Diaminopropionic acid derivatives

Details Diaminopropionic acid derivatives Diaminopropionic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 235/52 (2006.01) A61K 31/166 (2006.01) A61K 31/197 (2006.01) A61P 7/00 (2006.01) C07C 233/63 (2006.01) C07C 233/78 (2006.01) C07C 233/83 (2006.01) C07C 235/34 (2006.01) C07C 235/60 (2006.01) C07C 237/12 (2006.01) C07C 237/20 (2006.01) C07C 237/24 (2006.01) C07C 237/36 (2006.01) C07D 333/38 (2006.01) C07D 333/40 (2006.01)

Patent

CA 2344058

Compounds of the formula (1a), wherein R1 is a group of the formula (2) where R1, R2, A, B, U, V, W, X, Y, Z, k and n have the significance given in the specification, are useful to treat rheumatoid arthritis, psoriasis, multiple sclerosis, Crohn's disease, ulcerative colitis, artherosclerosis, restenosis, pancreatitis, transplant rejection, delayed graft function and diseases of ischemia reperfusion injury, including acute myocardial infraction and stroke.

L'invention concerne les composés de la formule (1a), dans laquelle R1 est un groupe de la formule, dans laquelle R1, R2, A, B, U, V, W, X, Y, Z, k et n ont la signification donnée dans la spécification. Lesdits composés sont utiles au traitement de la polyarthrite rhumatoïde, du psoriasis, de la sclérose en plaques, de la maladie de Crohn, de la rectocolite hémorragique, de l'artériosclérose, de la resténose, de la pancréatite, de rejets de greffes, de la fonction de greffe retardée, et de lésions ischémiques de reperfusion, y compris l'infarctus du myocarde aigu et l'ictus.

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