Diaminopyrimidines as p2x3 and p2x2/3 antagonists

Details Diaminopyrimidines as p2x3 and p2x2/3 antagonists Diaminopyrimidines as p2x3 and p2x2/3 antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61P 13/00 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2557372

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonists, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

L'invention concerne des composés et des procédés destinés au traitement de maladies induites par un antagoniste récepteur de P2X¿3? et/ou P2X¿2/3?. Ces procédés consistent à administrer à un sujet le nécessitant une quantité efficace d'un composé représenté par la formule (I) ou un sel, un solvate ou un promédicament de ces composés acceptables sur le plan pharmaceutique. Dans la formule (I), D, X, Y, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ sont tels que définis dans la description.

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