Diaminopyrimidines as p2x3 and p2x2/3 modulators

A - Human Necessities – 61 – K

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Details

A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2620034

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

La présente invention concerne des procédés de traitement de maladies respiratoires et gastroinstestinales facilitées par un P2X3et/ou un antagoniste du récepteur P2X2/3, les procédés comprenant l~administration à un sujet ayant besoin d~une quantité effective d~un composé de formule (I) ou un sel pharmaceutiquement acceptable en découlant, où D, X, Y, R1, R2, R3, R4, R5, R6, R7 et R8 sont tels que définis ici.

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