Diaminopyrimidines as p2x3 and p2x2/3 modulators

Details Diaminopyrimidines as p2x3 and p2x2/3 modulators Diaminopyrimidines as p2x3 and p2x2/3 modulators

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2619919

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I), wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

La présente invention concerne des composés et des procédés destinés au traitement de maladies ayant pour origine un antagoniste de récepteur P2X3 et/ou P2X2/3, les procédés comprenant l~administration à un sujet le nécessitant d~une quantité efficace d'un composé répondant à la formule (I), D, X, R1, R2, R3, R4, R5, R6, R7 et R8 étant tels que définis dans la description.

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