Diaminopyrimidines as p2x3 and p3x2/3 modulators

Details Diaminopyrimidines as p2x3 and p3x2/3 modulators Diaminopyrimidines as p2x3 and p3x2/3 modulators

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2619898

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

La présente invention concerne des composés répondant à la formule (I) ou des sels de ceux-ci pharmaceutiquement acceptables, A, D, E, G, J, X, Y, Z, R6, R7 et R8 étant tels définis dans la description. La présente invention fournit également des procédés utilisant les composés pour traiter des maladies ayant pour origine un antagoniste de récepteur P2X3 et/ou P2X2/3, et des procédés de fabrication des composés.

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