C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/517 (2006.01) A61P 5/50 (2006.01)
Patent
CA 2523960
The invention relates to diaminopyrroloquinazoline compounds of formula (I) wherein R1, Ra, Rb, Rc, Rd, Re, Rf and A are as defined in the specification and claims, which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
L'invention concerne des composés de diaminopyrroloquinazoline de formule (I), dans laquelle R¿1?, Ra, Rb, Rc, Rd, Re, Rf et A sont tels que définis dans la spécification et les revendications, lesquels composés sont utiles pour inhiber des protéine tyrosine phosphatases, en particulier PTP¿1?B, et pour abaisser des glycémies chez les mammifères.
Berthel Steven Joseph
Cheung Adrian Wai-Hing
Kim Kyungjin
Thakkar Kshitij Chhabilbhai
Yun Weiya
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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